BDBM22420 (cyclohexylmethyl)({[1-(4-methylphenyl)-1H-indol-3-yl]methyl})amine::Indole compound 1a::Inverse agonist

SMILES Cc1ccc(cc1)-n1cc(CNCC2CCCCC2)c2ccccc12

InChI Key InChIKey=MMIJMYOYKAKQPN-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22420   

TargetSteroid hormone receptor ERR1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM22420((cyclohexylmethyl)({[1-(4-methylphenyl)-1H-indol-3...)
Affinity DataIC50:  190nMAssay Description:Agonist activity at 6his-tagged ERRalpha LBD assessed as recruitment of GST-labeled coactivator Scr2 by TR-FRET assayMore data for this Ligand-Target Pair
TargetSteroid hormone receptor ERR1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM22420((cyclohexylmethyl)({[1-(4-methylphenyl)-1H-indol-3...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:The IC50s of compounds were determined in the FRET assay, which was conducted as time-resolved measurement (TR-FRET) in a 1536 well plate format. The...More data for this Ligand-Target Pair